Figure 3.

Transmission electron micrographs (TEM) of CRE(+);NOTCH-IC mouse glomeruli. (A) P42 CRE(−);NOTCH-IC mouse glomerulus. cap., patent capillary lumina. (B) P42 CRE(+);NOTCH-IC mouse glomerulus. cap., decreased capillary lumen diameter. White * denotes mesangial matrix expansion. (C) Podocyte-endothelial interface of a CRE(−);NOTCH-IC glomerular capillary loop. fp, normal foot processes. White arrow, normal glomerular basement membrane. (D) Corresponding interface from a CRE(+);NOTCH-IC glomerulus. Single black arrow, focal foot process effacement; double black arrows, normal-appearing foot processes; white arrow, glomerular basement membrane neither thickened nor split. Magnifications: ×2200 in A and B; ×13,000 in C and D.