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. 1999 Nov 9;96(23):13462–13467. doi: 10.1073/pnas.96.23.13462

Figure 1.

Figure 1

Postnatal development in Ink4d, Kip1-deficient mice. (A) Immunoblotting of brain extracts from mice of the different genotypes. Recombinant proteins produced in insect Sf9 cells infected with the indicated baculovirus vectors (lanes 1) or wild-type baculovirus (lane 2) were used as controls. Genotypes: wild type (lane 3), double-null (lane 4), Kip1-null (lane 5), and Ink4d-null (lane 6). (B) At P18, Ink4d, Kip1 double-null mice appear consistently smaller than their wild-type littermates. (C) When lifted by their tails, wild-type mice twist, extend their legs, and attempt to find a solid object to grasp, including climbing back up their own tails, whereas (D) double-null mice hold their limbs by their trunk. (E) By P18, Ink4d, Kip1 double-null mice exhibit seizures and have difficulty righting themselves. (F) Body weights of postnatal mice at different ages [± SEM] for wild type (♦), Ink4d-null (□), Kip1-null (Δ), or Ink4d, Kip1 double-null (●) mice.