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. 2008 Mar 13;94(12):4678–4687. doi: 10.1529/biophysj.107.121590

FIGURE 3.

FIGURE 3

Mutations of voltage-sensing residues significantly reduced the β1-induced enhancement of Ca2+ sensitivity. (A and B) V1/2-[Ca2+]i relationships of WT, R167A, and D186A mSlo1 channels with and without β1-subunit. (C) V1/2-[Ca2+]i relationship of E386A and D153C:E386A mSlo1 channels with and without β1-subunit. The G-V relationship of D153C:E386A is shifted too far rightward to record any measurable currents at 0.5 nM [Ca2+]i. (D) V1/2–[Ca2+]i relationship of E321A and R213C:E321A mSlo1 channels with and without β1-subunit.