FIGURE 1.
Schematic view of the archaeon Pyrococcus woesei TATA binding protein (green ribbon) in complex with DNA (orange), and transcription factor II (cyan ribbon) of the crystal structure (PDB entry 1AIS). Residues that are subject to mutations are indicated as red spheres and labeled by residue number and one-letter amino acid codes (E, Glu; D, Asp). The N-terminal (Met-1) and C-terminal (Tyr-181) ends of the PwTBP are labeled, and the 5′- and 3′-ends of the DNA are indicated. (A) View of the binding interface to DNA. (B) View along the z axis.