TABLE 4.

Basic lipid properties and effects of LL-37 at physiological conditions

	PC	PG	PS	PE
Net charge	0	−1	−1	0
Molecular shape/curvature (from Israelachvili et al. (50))	Cylindrical/0	Cylindrical/0	Cylindrical/0	Truncated cone/negative
Chain tilt θt*	31.6°, from (51)	29.5°, from (31)	–	–
H-bonding ability	No	No	Yes	Yes
Headgroup area A*†	48.1 Å2	47.1 Å2	40.6 Å2	40.3 Å2
Effect of LL-37*	Disk-like micelles with peptide rim	Quasi-interdigitation	Surface binding, unperturbed bilayer	None
Effect of LL-37‡	Fused disks, minor thinning	Major membrane thinning	Unbinding of bilayers	None

^*Gel phase (25°C).

^†Calculated from WAXS data.

^‡Fluid phase.