FIGURE 2.

Linker region of C-cadherin repeats EC1-EC2. (A–D) Snapshots of the linker region between repeats EC1-EC2 of C-cadherin after 1.1 ns of simulation for systems with crystallographically resolved Ca²⁺, without Ca²⁺, with K⁺, and with Na⁺ ions, respectively. The protein is shown in orange cartoon representation and ions are shown as green (Ca²⁺), dark yellow (K⁺), and light yellow (Na⁺) spheres. Residues originally involved in Ca²⁺ binding are labeled and shown for all snapshots in licorice representation.