Table 2.

Evolutionary sequence conservation of human TFBS.

Category	Site	Contact	Context
Non-repetitive	0.407 ± 0.085	0.410 ± 0.074	0.400 ± 0.110
All repeats	0.115 ± 0.042	0.130 ± 0.041	0.088 ± 0.045
All SSR	0.170 ± 0.056	0.183 ± 0.052	0.145 ± 0.062
All TEs	0.047 ± 0.026	0.059 ± 0.026	0.028 ± 0.026
Alu	0.002 ± 0.002	0.003 ± 0.003	0.002 ± 0.001
MIR	0.028 ± 0.017	0.048 ± 0.026	0.003 ± 0.004
L1	0.068 ± 0.063	0.077 ± 0.068	0.047 ± 0.052
All other LINEs	0.066 ± 0.018	0.095 ± 0.022	0.012 ± 0.011
LTR	0.141 ± 0.076	0.145 ± 0.042	0.136 ± 0.119
DNA	0.043 ± 0.029	0.057 ± 0.038	0.016 ± 0.009

Average (± standard deviation) base-by-base conservation levels are shown for different categories, non-repetitive and repetitive, of human TFBS. TFBS derived from repetitive DNA are broken down SSR versus TE-derived, and TE-derived TFBS are divided into specific classes/families of elements. Base-by-base conservation levels were averaged separately across entire sites, and across contact versus context positions.