Table 3.

Correlation of HIF-1α, p53, and VEGF expression with preoperative sVEGF level

	p53			HIF-1α			VEGF
	-	+	P	-/S	D/V	P	Under	Over	P
HIF-1α
-/S	58	38	0.617*
D/V	12	6
VEGF
Under	33	15	0.169*	40	8	0.827*
Over	37	29		56	10
sVEGF (pg/ml)
Median	103	139	0.705†	147	77	0.438†	153	163	0.146†
(range)	(8–1076)	(6–642)		(6–1076)	(6–761)		(8–1076)	(6–761)

* by χ² test, ^† by Mann-Whitney U test

HIF-1α: hypoxia-inducible factor 1 alpha, VEGF: vascular endothelial growth factor, sVEGF: preoperative serum vascular endothelial growth factor, -/S: negative/superficial pattern, D/V: deep/diffuse/vascular invasion pattern, Under: under-expressed, Over: over-expressed