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Inhibition of PbTx-2 effect by ΔΔBj-xtrIT. A and B, alteration in conductance-voltage relations of DmNav1/TipE (A) and rNav1.2/hβ1(B) by PbTx-2 in the presence or absence of ΔΔBj-xtrIT. Toxin concentrations and the activation parameters (V½) are as described in Table 1. Inset, rNav1.2/hβ1 currents induced by the indicated toxin in a test pulse to -35 mV. Similar results were obtained with ΔΔCss4 (Table 1).
