FIGURE 6.

Isolation of MbCsk. MbCsk was isolated by PCR from an M. brevicollis cDNA library. The figure shows the domain arrangement of Csk and an alignment of human, fly, hydra, sponge, M. brevicollis, and M. ovata Csk sequences. The SH3 domain sequence is shaded yellow, the SH2 domain is green, and the catalytic domain is blue. Arrowheads indicate substrate docking sites in Csk that are important for Src recognition (44). Red arrowheads show residues that are conserved between human Csk and MbCsk, and the white arrowheads show non-conserved residues.