Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model of STIM1 mediated ER-PM interactions via its coiled-coil domain. ER-STIM1 forms oligomers after store depletion that relocalize close to the PM. A, ER-STIM1 oligomers relocalized close to the PM interact with PM-STIM1 and/or Orai1 protein to activate CRAC channel. B, the interaction between the ER and the PM is abolished by the kink introduced in the coiled-coil domain of STIM1 by L286P/L292P mutation.
