Table 1.
Loa/+ [1,13,20] | Cra1/+ [13] | Swl/+ [1] | |
---|---|---|---|
Mutation | F580Y | Y1055C | [GIVT]1040 [A] |
Lifespan | Normal | Normal | Normal |
Progressive phenotype | Mildly | Mildly | No |
Limb clenching | Yes | Yes | Yes |
Gait abnormalities | Yes | Yes | Yes |
Forelimb grip strength | Reduced | Unknown | Normal |
Hindlimb grip strength | Reduced | Reduced | Reduced |
Muscle pathology | Normal | Abnormal | Normal |
Loss of muscle spindles | Yes | Unknown | Yes |
Nociception | * | Unknown | No |
Proprioception | Abnormal | Unknown | Abnormal |
H reflex | Absent | Unknown | Absent |
Loss of lumbar DRG neurons | Yes | Unknown | Yes |
Loss of cervical DRG neurons | Mild† | Unknown | No |
Size of ventral root | Normal | Unknown | Normal |
Size of dorsal root | Thin | Unknown | Thin |
Diameter of sciatic nerve | Thin‡ | Unknown | Thin |
Loss of alpha motor neurons in spinal cord | Mild | Mild | No |
Attenuates SOD1G93A | Yes | Yes | No |
*Tendency to longer time in tail-flick test, but never shown to be statistically significant (Rogers D, EMCF, Martin JE, unpublished data). †Not statistically significant. ‡(Bros V, EMCF and Greensmith L, unpublished data).