Table 4.
Details of representative functionally important fragments of FL8 enumerated using GO level 3
| PDB (group number)* | GO MF (EC number) | PROSITE pattern | Molecular function | Functionally important fragment(s) (start: sequence (propensity))† | P-value |
|---|---|---|---|---|---|
| 1df9A (1) | 0003724 (3.4.21.91) | - | Dengue virus NS3 protease | 132: PGTSGSPI (30) | 4.17e-5 |
| 133: GTSGSPII (40) | 5.95e-8 | ||||
| 156: TRSGAYVS (24) | 0.007 | ||||
| 1e7uA (2) | 0016773 (2.7.1.153) | PS00915 | Phosphatidyl-inositol 3- and 4-kinase signatures 1 and 2 | 857: TESLDLCL (48) | 0.02 |
| PS00916 | 861: DLCLLPYG (23) | 0.04 | |||
| 872: TGDKIGMI (29) | 0.03 | ||||
| 1tgj (3/4) | 0005160 | PS00250‡ | Cytokines (repair of tissue) | 27: DLGWKWVH (305) | 0.04 |
*The chain identifier is given after the four letter PDB code, wherever present. †Amino acids in bold either directly or indirectly participate in the enzyme function. ‡PROSITE pattern: (33-48, VHEPKGYYANFCSGPC).