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. 2008 Mar 20;10(2):401. doi: 10.1186/bcr1866

Table 2.

Example of clinical application: BRCA1 and BRCA2 carrier probabilities (%) under selected marker profile scenarios

Cancer history

Counselee: 54 year old with breast cancer at 45 Mother: breast cancer at 63 Estimated carrier probabilities (%)



ER CK14 CK5/6 PR ER CK14 CK5/6 PR BRCA1 BRCA2
. . . . . . . . 2.2 2.3
- . . . . . . . 5.5 2.3
+ . . . . . . . 0.35 2.4
. . . - . . . . 4.6 2.3
. . . + . . . . 0.75 2.4
- + + . . . . . 38 1.5
- . . . - . . . 11 2.1
- . . . + . . . 2.1 2.3
- + + . - + + . 36 1.5
- + - . - + - + 2.1 2.3

No other family history is available. Plus signs (+) denote positive; hyphens (-) denote negative; periods (.) denote missing.