Table 2.
Example of clinical application: BRCA1 and BRCA2 carrier probabilities (%) under selected marker profile scenarios
Cancer history | |||||||||
Counselee: 54 year old with breast cancer at 45 | Mother: breast cancer at 63 | Estimated carrier probabilities (%) | |||||||
ER | CK14 | CK5/6 | PR | ER | CK14 | CK5/6 | PR | BRCA1 | BRCA2 |
. | . | . | . | . | . | . | . | 2.2 | 2.3 |
- | . | . | . | . | . | . | . | 5.5 | 2.3 |
+ | . | . | . | . | . | . | . | 0.35 | 2.4 |
. | . | . | - | . | . | . | . | 4.6 | 2.3 |
. | . | . | + | . | . | . | . | 0.75 | 2.4 |
- | + | + | . | . | . | . | . | 38 | 1.5 |
- | . | . | . | - | . | . | . | 11 | 2.1 |
- | . | . | . | + | . | . | . | 2.1 | 2.3 |
- | + | + | . | - | + | + | . | 36 | 1.5 |
- | + | - | . | - | + | - | + | 2.1 | 2.3 |
No other family history is available. Plus signs (+) denote positive; hyphens (-) denote negative; periods (.) denote missing.