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. 2008 Mar 10;10(2):R23. doi: 10.1186/bcr1875

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Copyright © 2008 Wall et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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FRI of different tumour xenografts over time. (a) White light images of different tumour xenografts (as indicated), followed by fluorescence reflectance imaging (FRI) images taken sequentially after application of 2 μmol/kg body weight SIDAG. Note the strong fluorescence signal in the HT1080 (n = 11) fibrosarcomas and in the MDA-MB435 (n = 10) melanomas, whereas the MCF7 (n = 9) and DU4475 (n = 13) adenocarcinomas exhibit only moderate tumour fluorescence. (b) Quantitative data analysis revealed significantly higher contrast to noise ratios (CNRs) for the HT180 and MDA-MB435 xenografts compared with the MCF7 and the DU4475 tumours.