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Schematic diagram of the study design. Proposed trial design for preoperative chemotherapy in operable breast cancer, exploring in vivo chemosensitivity as a decision-maker for the use of non-cross-resistant salvage chemotherapy in non-responding patients. TAC: Taxotere (docetaxel), Adriblastin (doxorubicin) and cyclophosphamide; NX: Navelbine (vinorelbine) and Xeloda (capecitabine).
