Table 4.
Odds ratios for postmenopausal breast cancer by genotypes in the vitamin D receptor gene according to ER and PR status of the tumour
| Genotype | ER-positive tumours | ER-negative tumours | PR-positive tumours | PR-negative tumours | |||||
| n (controls) | n (cases) | OR (95% CI) | n (cases) | OR (95% CI) | n (cases) | OR (95% CI) | n (cases) | OR (95% CI) | |
| TaqI | |||||||||
| TT | 980 | 337 | 1 | 121 | 1 | 297 | 1 | 159 | 1 |
| Tt/tt | 1,629 | 653 | 1.18 (1.00–1.38) | 186 | 0.88 (0.69–1.13) | 547 | 1.10 (0.93–1.30) | 293 | 1.11 (0.89–1.37) |
| FokI | |||||||||
| FF | 998 | 394 | 1 | 127 | 1 | 331 | 1 | 190 | 1 |
| Ff/ff | 1,598 | 586 | 0.95 (0.81–1.10) | 177 | 0.86 (0.67–1.10) | 505 | 0.96 (0.82–1.14) | 257 | 0.84 (0.68–1.03) |
| VDR-5132 | |||||||||
| CC | 892 | 347 | 1 | 113 | 1 | 298 | 1 | 162 | 1 |
| CT/TT | 1,715 | 640 | 0.99 (0.84–1.16) | 194 | 0.92 (0.71–1.18) | 543 | 0.97 (0.82–1.15) | 290 | 0.97 (0.78–1.20) |
| Cdx2 | |||||||||
| GG | 1,701 | 641 | 1 | 190 | 1 | 546 | 1 | 283 | 1 |
| GA/AA | 905 | 351 | 1.01 (0.86–1.17) | 118 | 1.14 (0.88–1.46) | 301 | 1.01 (0.86–1.20) | 169 | 1.11 (0.90–1.38) |
We conducted a conditional logistic regression stratified by year of birth adjusted for age at menopause, first-degree family history of breast cancer, history of benign breast disease, number of pregnancies (≥28th week), age at menarche, breastfeeding history, total number of mammograms, use of hormone therapy, body mass index, education level and smoking status. Data on oestrogen receptor (ER) and progesterone receptor (PR) status was available for 1,302 and 1,301 cases, respectively.