Table 1.
Distribution of select risk factors across categories of aspirin use among 126,124 women, National Institutes of Health–AARP Study
| Frequency of aspirin use in past 12 months | ||||||||
| None | <weekly | 1–6 times/week | 1+/day | |||||
| Characteristic | n | %a | n | %a | n | %a | n | %a |
| Age at second questionnaire | ||||||||
| <57 years | 8,178 | 19.0 | 8,629 | 21.7 | 4,029 | 20.1 | 2,936 | 13.3 |
| 57–60 years | 8,317 | 19.4 | 8,211 | 20.6 | 4,022 | 20.1 | 3,566 | 16.2 |
| 61–64 years | 9,750 | 22.7 | 9,025 | 22.7 | 4,644 | 23.2 | 5,132 | 23.2 |
| 65–68 years | 11,085 | 25.8 | 9,459 | 23.8 | 4,881 | 24.3 | 6,607 | 29.9 |
| 69+ years | 5,630 | 13.1 | 4,457 | 11.2 | 2,481 | 12.4 | 3,839 | 17.4 |
| Race/ethnicity | ||||||||
| Caucasian/non-Hispanic white | 38,339 | 89.2 | 36,340 | 91.4 | 18,561 | 92.5 | 20,381 | 92.3 |
| Other/unknown | 4,621 | 10.8 | 3,441 | 8.6 | 1,496 | 7.5 | 1,699 | 7.7 |
| Education | ||||||||
| <High school/high school grad | 13,537 | 32.5 | 10,675 | 27.5 | 5,769 | 29.6 | 6,857 | 32.0 |
| Post-high school+ | 28,171 | 67.5 | 28,110 | 72.5 | 13,696 | 70.4 | 14,554 | 68.0 |
| Body mass index at baseline | ||||||||
| <25 kg/m2 | 18,461 | 44.7 | 18,855 | 48.9 | 9,040 | 46.6 | 8,718 | 40.8 |
| 25–30 kg/m2 | 13,144 | 31.8 | 12,331 | 32.0 | 6,407 | 33.0 | 7,290 | 34.2 |
| 30+ kg/m2 | 9,719 | 23.5 | 7,342 | 19.1 | 3,965 | 20.4 | 5,335 | 25.0 |
| Smoking | ||||||||
| Never | 19,321 | 46.3 | 18,123 | 47.0 | 8,996 | 46.4 | 8,984 | 42.1 |
| Former | 16,758 | 40.2 | 15,314 | 39.7 | 7,735 | 39.9 | 9,184 | 43.0 |
| Current | 5,630 | 13.5 | 5,137 | 13.3 | 2,656 | 13.7 | 3,193 | 14.9 |
| Alcoholic drinks | ||||||||
| 0 drinks per day | 14,515 | 33.8 | 9,136 | 23.0 | 4,784 | 23.9 | 7,009 | 31.7 |
| <1 drink per day | 23,322 | 54.3 | 24,771 | 62.3 | 12,299 | 61.3 | 12,111 | 54.9 |
| 1–3 drinks per day | 4,037 | 9.4 | 4,727 | 11.9 | 2,382 | 11.9 | 2,297 | 10.4 |
| 3+ drinks per day | 1,086 | 2.5 | 1,147 | 2.9 | 592 | 3.0 | 663 | 3.0 |
| Self-reported general health | ||||||||
| Excellent/very good/good | 36,189 | 85.6 | 36,638 | 93.3 | 17,869 | 90.4 | 17,868 | 82.4 |
| Fair/poor | 6,094 | 14.4 | 2,639 | 6.7 | 1,891 | 9.6 | 3,814 | 17.6 |
| Stroke | ||||||||
| No | 42,293 | 98.4 | 39,557 | 99.4 | 19,844 | 98.9 | 21,112 | 95.6 |
| Yes | 667 | 1.6 | 224 | 0.6 | 213 | 1.1 | 968 | 4.4 |
| Heart disease | ||||||||
| No | 39,820 | 92.7 | 38,292 | 96.3 | 18,924 | 94.4 | 17,561 | 79.5 |
| Yes | 3,140 | 7.3 | 1,489 | 3.7 | 1,133 | 5.6 | 4,519 | 20.5 |
| High blood pressure | ||||||||
| No | 24,240 | 60.2 | 25,179 | 67.7 | 11,484 | 61.5 | 9,502 | 46.1 |
| Yes | 16,001 | 39.8 | 11,997 | 32.3 | 7,192 | 38.5 | 11,117 | 53.9 |
| Mammogram in past 3 years | ||||||||
| Once or less | 13,226 | 31.0 | 12,161 | 30.8 | 6,043 | 30.4 | 6,496 | 29.8 |
| Yes, more than once | 29,408 | 69.0 | 27,298 | 69.2 | 13,827 | 69.6 | 15,327 | 70.2 |
| Age at menarche | ||||||||
| <13 years | 21,222 | 49.8 | 18,850 | 47.8 | 9,679 | 48.7 | 11,036 | 50.4 |
| 13–14 years | 17,452 | 41.0 | 17,101 | 43.4 | 8,407 | 42.3 | 8,859 | 40.5 |
| 15+ years | 3,909 | 9.2 | 3,492 | 8.9 | 1,792 | 9.0 | 1,981 | 9.1 |
| Parity | ||||||||
| Nulliparous | 6,253 | 14.8 | 5,996 | 15.3 | 2,808 | 14.2 | 3,089 | 14.3 |
| One | 4,459 | 10.6 | 4,056 | 10.4 | 2,009 | 10.2 | 2,172 | 10.0 |
| Two | 11,052 | 26.2 | 10,488 | 26.8 | 5,290 | 26.8 | 5,406 | 25.0 |
| Three or more | 20,431 | 48.4 | 18,578 | 47.5 | 9,608 | 48.7 | 10,987 | 50.7 |
| Age at first live birth | ||||||||
| Nulliparous | 6,253 | 14.8 | 5,996 | 15.3 | 2,808 | 14.2 | 3,089 | 14.2 |
| <20 years | 7,385 | 17.4 | 6,016 | 15.3 | 3,319 | 16.8 | 3,895 | 17.9 |
| 20–24 years | 18,472 | 43.6 | 17,112 | 43.6 | 8,861 | 44.9 | 9,800 | 45.1 |
| 25–29 years | 7,636 | 18.0 | 7,582 | 19.3 | 3,632 | 18.4 | 3,739 | 17.2 |
| 30+ years | 2,575 | 6.1 | 2,499 | 6.4 | 1,129 | 5.7 | 1,191 | 5.5 |
| Age at menopause | ||||||||
| Premenopausal | 1,462 | 3.4 | 1,738 | 4.4 | 742 | 3.7 | 445 | 2.0 |
| <45 years | 2,834 | 6.6 | 2,429 | 6.1 | 1,266 | 6.3 | 1,593 | 7.2 |
| 45–49 years | 6,543 | 15.2 | 6,316 | 15.9 | 2,997 | 14.9 | 3,358 | 15.2 |
| 50–54 years | 11,362 | 26.4 | 11,870 | 29.8 | 5,415 | 27.0 | 5,732 | 26.0 |
| 55+ years | 2,650 | 6.2 | 2,555 | 6.4 | 1,218 | 6.1 | 1,284 | 5.8 |
| Surgical menopause | 16,770 | 39.0 | 13,577 | 34.1 | 7,754 | 38.7 | 8,975 | 40.6 |
| Postmenopausal, age unknown | 1,339 | 3.1 | 1,296 | 3.3 | 665 | 3.3 | 693 | 3.1 |
| Hormone therapy formulation | ||||||||
| Never used | 17,328 | 42.4 | 15,676 | 41.2 | 7,201 | 37.6 | 8,371 | 39.8 |
| Estrogen therapy only | 11,901 | 29.1 | 10,157 | 26.7 | 5,844 | 30.5 | 6,724 | 32.0 |
| Estrogen–progestin therapy | 11,681 | 28.6 | 12,196 | 32.1 | 6,100 | 31.9 | 5,945 | 28.3 |
| Moderate/vigorous physical activity during past 10 years | ||||||||
| Never | 1,801 | 4.3 | 1,033 | 2.6 | 545 | 2.8 | 878 | 4.0 |
| Rarely | 4,911 | 11.6 | 4,012 | 10.2 | 1,986 | 10.1 | 2,539 | 11.7 |
| <1 hour/week | 4,473 | 10.6 | 4,102 | 10.5 | 2,107 | 10.7 | 2,347 | 10.8 |
| 1–3 hours/week | 10,495 | 24.9 | 10,085 | 25.7 | 5,240 | 26.6 | 5,457 | 25.1 |
| 4–7 hours/week | 10,379 | 24.6 | 10,438 | 26.6 | 5,311 | 26.9 | 5,371 | 24.7 |
| >7 hours/week | 10,100 | 24.0 | 9,548 | 24.3 | 4,546 | 23.0 | 5,122 | 23.6 |
| Number breast biopsies | ||||||||
| None | 32,240 | 75.8 | 30,183 | 76.6 | 14,985 | 75.4 | 16,551 | 75.8 |
| One | 6,819 | 16.0 | 6,175 | 15.7 | 3,217 | 16.2 | 3,428 | 15.7 |
| Two | 1,904 | 4.5 | 1,666 | 4.2 | 926 | 4.7 | 997 | 4.6 |
| Three or more | 1,581 | 3.7 | 1,360 | 3.5 | 737 | 3.7 | 863 | 4.0 |
| Family history of breast cancer in first degree relative (male or female) | ||||||||
| No | 29,536 | 83.5 | 27,782 | 83.8 | 13,814 | 83.6 | 14,930 | 83.4 |
| Yes | 5,838 | 16.5 | 5,356 | 16.2 | 2,708 | 16.4 | 2,978 | 16.6 |
aMissing values were excluded from percentage calculations.