Table 3.
Number of cancers | Person-years | Relative riska | 95% confidence interval | P value for trend | |
NSAID use | |||||
Never | 667 | 124,265 | 1.00 (referent) | n/a | |
Aspirin only | 1,085 | 203,145 | 0.97 | 0.88 to 1.07 | |
Non-aspirin NSAID only | 874 | 157,017 | 1.01 | 0.92 to 1.12 | |
Both | 1,781 | 334,792 | 0.95 | 0.87 to 1.04 | |
Aspirin useb | |||||
Never | 1,556 | 284,342 | 1.00 (referent) | 0.08 | |
<1/week | 1,405 | 265,676 | 0.95 | 0.89 to 1.03 | |
1–6/week | 716 | 133,331 | 0.95 | 0.87 to 1.04 | |
1+/day | 774 | 145,317 | 0.93 | 0.85 to 1.01 | |
Non-aspirin NSAID useb | |||||
Never | 1,764 | 329,944 | 1.00 (referent) | 0.58 | |
<1/week | 1,415 | 262,000 | 1.00 | 0.93 to 1.07 | |
1–6/week | 693 | 126,373 | 1.02 | 0.93 to 1.11 | |
1+/day | 585 | 109,098 | 0.96 | 0.87 to 1.05 |
aAdjusted for age (continuous), race, age at first birth, hormone therapy use, number of breast biopsies, alcohol intake, history of hypertension, and family history of breast cancer in first-degree relative.
bThese models also include terms for frequency of use of opposite NSAID type.