Figure 1.
(a) Minocycline treatment started 12 h before ischemia does not alter body temperature (T), mean arterial blood pressure (MABP), arterial PO2, PCO2, pH, or plasma glucose, as determined by measurements taken during the ischemia or 15 min after the ischemia (n = 5 in each group). (b) Minocycline treatment started 12 h before (pretreated) or 2 h after (posttreated) the onset of ischemia reduces the infarction area seen in triphenyltetrazolium chloride-stained brain slices 3 days after ischemia compared with saline-treated animals. (c) The infarction area is significantly reduced in the cortex and striatum compared with saline-treated animals when the minocycline treatment is started 12 h before ischemia (Pre, n = 10), 2 h after the onset of ischemia (Post, n = 10), or 4 h after the onset of ischemia (Post 4 h, n = 12). Values are means ± SD. *, P < 0.01 (one-way ANOVA followed by the Bonferroni test).