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. 1994 Mar;70(821):225–227. doi: 10.1136/pgmj.70.821.225

A case of isolated TSH deficiency presenting as infertility.

A H Balen 1, P J Manning 1
PMCID: PMC2397864  PMID: 8183759

Abstract

We report a case of late-onset isolated thyroid stimulating hormone deficiency in a woman who presented with oligomenorrhoea and secondary hyperprolactinaemia. Hypothalamic and pituitary radiology and function was otherwise normal. The underlying aetiology of this condition is thought to be due to an inborn defect in the thyrotroph and treatment is with standard thyroid replacement therapy.

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Selected References

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  1. Burke C. W., Moore R. A., Rees L. H., Bottazzo G. F., Mashiter K., Bitensky L. Isolated ACTH deficiency and TSH deficiency in the adult. J R Soc Med. 1979 May;72(5):328–335. doi: 10.1177/014107687907200505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Castaing H., Fournet J. P., Léger F. A., Kiesgen F., Piette C., Dupard M. C., Savoie J. C. Thyroïde du nouveau-né et surcharge en iode après la naissance. Arch Fr Pediatr. 1979 Apr;36(4):356–368. [PubMed] [Google Scholar]
  3. Gharib H., Abboud C. F. Primary idiopathic hypothalamic hypothyroidism. Report of four cases. Am J Med. 1987 Jul;83(1):171–174. doi: 10.1016/0002-9343(87)90515-8. [DOI] [PubMed] [Google Scholar]
  4. Hayashizaki Y., Hiraoka Y., Endo Y., Miyai K., Matsubara K. Thyroid-stimulating hormone (TSH) deficiency caused by a single base substitution in the CAGYC region of the beta-subunit. EMBO J. 1989 Aug;8(8):2291–2296. doi: 10.1002/j.1460-2075.1989.tb08355.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Katakami H., Kato Y., Inada M., Imura H. Hypothalamic hypothyroidism due to isolated thyrotropin-releasing hormone (TRH) deficiency. J Endocrinol Invest. 1984 Jun;7(3):231–233. doi: 10.1007/BF03348429. [DOI] [PubMed] [Google Scholar]
  6. Labbe A., Dubray C., Gaillard G., Besse G., Assali P., Malpuech G. Familial growth retardation with isolated thyroid-stimulating hormone deficiency. Clin Pediatr (Phila) 1984 Dec;23(12):675–678. doi: 10.1177/000992288402301202. [DOI] [PubMed] [Google Scholar]
  7. Miyai K., Azukizawa M., Kumahara Y. Familial isolated thyrotropin deficiency with cretinism. N Engl J Med. 1971 Nov 4;285(19):1043–1048. doi: 10.1056/NEJM197111042851902. [DOI] [PubMed] [Google Scholar]
  8. Miyai K., Endo Y., Iijima Y., Kabutomori O., Hayashizaki Y. Serum free thyrotropin subunit in congenital isolated thyrotropin deficiency. Endocrinol Jpn. 1988 Jun;35(3):517–521. doi: 10.1507/endocrj1954.35.517. [DOI] [PubMed] [Google Scholar]
  9. Mori R., Sawai T., Kinoshita E., Baba T., Matsumoto T., Yoshimoto M., Tsuji Y., Satake Y., Sawada K. Rapid detection of a point mutation in thyroid-stimulating hormone beta-subunit gene causing congenital isolated thyroid-stimulating hormone deficiency. Jinrui Idengaku Zasshi. 1991 Dec;36(4):313–316. doi: 10.1007/BF01883604. [DOI] [PubMed] [Google Scholar]
  10. Penel C., Rognoni J. B., Bastiani P. Thyroid autoregulation: impact on thyroid structure and function in rats. Am J Physiol. 1987 Aug;253(2 Pt 1):E165–E172. doi: 10.1152/ajpendo.1987.253.2.E165. [DOI] [PubMed] [Google Scholar]
  11. Sachson R., Rosen S. W., Cuatrecasas P., Roth J., Frantz A. G. Prolactin stimulation by thyrotropin-releasing hormone in a patient with isolated thyrotropin deficiency. N Engl J Med. 1972 Nov 9;287(19):972–973. doi: 10.1056/NEJM197211092871909. [DOI] [PubMed] [Google Scholar]

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