Figure 2.

(A) Nucleotide sequence and the predicted amino acid sequence of the human brain 3α-HSD clone. The ORF contains 969 nucleotides and encodes a protein of 323 amino acids. (B) Comparison of the amino acid sequences of mammalian 3α-HSDs. Only amino acids differing from the human brain type II_Brain 3α(20α, 17β)-HSD sequence are shown. Human type 1 is also chlordecone reductase and DD4 (21, 33); human type 3 is also bile acid binding protein (31); human 20αHSD is also DD1 (34, 35); x, no amino acid (rat 3αHSD is one amino acid shorter than the human forms).