Table 2.

Summary of human type III activity

DHP ⇒ allopregnanolone
	Km, nM	Vmax, nmol/mg/min	Enzyme efficiency
DHP alone	7.2  ± 0.01	126  ± 0.44	17.5
(+)fluoxetine	0.63  ± 0.01	169.8  ± 0.56	269.5
(+)paroxetine	0.26  ± 0.01	82.13  ± 0.69	316.5
(+)sertraline	0.69  ± 0.03	120.1  ± 0.57	174.1
(+)imipramine	9.93  ± 0.04	114.2  ± 3.53	11.5

Allopregnanolone ⇒ DHP
	Km, μM	Vmax, nmol/mg/min	Enzyme efficiency
Allo alone	43.0  ± 0.02	7.1  ± 0.01	0.0002
(+)fluoxetine	30.9  ± 0.03	27.0  ± 0.37	0.0008
(+)paroxetine	15.0  ± 0.01	8.9  ± 0.01	0.0006
(+)sertraline	130.4  ± 0.16	10.8  ± 0.43	0.00008
(+)imipramine	71.4  ± 0.22	39.0  ± 3.33	0.0005

Mean ± SE.