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. 1999 Nov 9;96(23):13518–13523. doi: 10.1073/pnas.96.23.13518

Figure 1.

Figure 1

NPY blockade of spontaneous epileptiform burst discharge in hippocampal slices from wild-type mice. Epileptiform activity was induced by slice perfusion with bathing medium containing no magnesium. (A) Field recordings were obtained simultaneously from CA1 (Upper) and CA3 (Lower) pyramidal cell layers. After ≈45 min of perfusion with 0-Mg-ACSF, spontaneous burst discharges occurred in CA1 and CA3. This discharge pattern was abolished after a 10-min perfusion with 0-Mg-ACSF containing 1 μM human NPY. Recovery of burst activity was seen within 15 min after return to 0-Mg-ACSF. (B) Spontaneous epileptiform burst discharges occurring in CA1 were abolished by perfusion with 0-Mg-ACSF containing 1 μM human NPY13–36; burst-discharge activity occurring in neocortex (layer II–III) was unchanged. (C) Spontaneous epileptiform burst discharges occurring in CA1 were abolished by perfusion with 0-Mg-ACSF containing 1 μM human pancreatic polypeptide.