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. 1999 Nov 9;96(23):13518–13523. doi: 10.1073/pnas.96.23.13518

Figure 3.

Figure 3

Response of wild-type and mutant mice to peripherally administered KA. Female wild-type (Y5R+/+), heterozygous (Y5R+/−), and homozygous Y5R−/− littermate mice on a mixed C57BL/6J × 129/Sv (A–F) genetic background or female wild-type and Y5R−/− mice on an inbred 129/Sv (G–I) genetic background were injected (i.p.) with either 20 (A–C) or 40 (D–I) mg/kg KA and observed for 2 hr after injection. (A, D, and G) Motor seizure severity was rated on a scale from 0 to 6 as described in Materials and Methods (n = 16–35 per genotype; *, P < 0.001). (B, E, and H) Latency to loss of posture (LOP), bilateral forelimb clonus (BFC), and death in response to KA was measured in minutes for control and mutant mice (n = 9–35 per genotype; *, P < 0.004). (C, F, and I) Plot of the percent mortality of control and mutant mice after KA administration (n = 16–35 per genotype).