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. 1991 Feb;65(2):989–991. doi: 10.1128/jvi.65.2.989-991.1991

Posttranscriptional regulation of interferon mRNA levels in peritoneal macrophages.

S Gessani 1, P Di Marzio 1, P Rizza 1, F Belardelli 1, C Baglioni 1
PMCID: PMC239845  PMID: 1898975

Abstract

Low levels of beta interferon (IFN) mRNA are transcribed in freshly explanted murine peritoneal macrophages. Nuclear runoff transcription assays show that this "constitutive" IFN-beta-mRNA transcription does not increase in macrophages treated either with lipopolysaccharide or with IFN-gamma, which induce a marked accumulation of this mRNA and greatly increase IFN secretion. Therefore, these agents promote accumulation of IFN-beta mRNA by posttranscriptional mechanisms. The IFN-alpha 2 gene is also constitutively transcribed by macrophages, but the corresponding mRNA does not accumulate in lipopolysaccharide-treated cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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