Table 1.
Effects of Topical fluoroquinolones on Collagenase-type Metalloproteinases Immunohistochemical detection at 48 Hours
| Type of eye drops | MMP-1 | MMP-8 | |
| Applied q.i.d. | Epithelium | ||
| Artificial Tear | Intact | 0/14 | 0/14 |
| Debrided | 14/14 | 13/14 | |
| Ciloxan | Intact | 14/14 ** | 13/14 ** |
| Debrided | 14/14 | 14/14 | |
| Ocuflox | Intact | 13/14** | 12/14** |
| Debrided | 14/14 | 14/14 | |
| Quixin | Intact | 13/14** | 12/14** |
| Debrided | 14/14 | 14/14 |
Double masked observer determined the total positive immunostained eyes for MMP-1 and MMP-8 in each test group. Immunoreactivity is reported as number of positively immunostained corneas / total number of corneas examined. ** Statistically different when comparing the corresponding fluoroquinolone group to artificial tear. (P < 0.05 using Fisher's exact test analysis).