Table 1.
IF proteins and IFAPs in mammalian cells
| Proteins | MW *(kDa) | Expression | References |
|---|---|---|---|
| IF Proteins: | |||
| Type I | 38,41,42,64,92 | ||
| Acidic keratins | 40–64 | Epithelia | |
| Type II | |||
| Basic keratins | 53–67 | Epithelia | |
| Type III | 1,8,12,25,26,38,53,63,64,87,103,113–115 | ||
| Vimentin | 56 | Mesenchyme, smooth muscle | |
| 53 | Muscle | ||
| GFAP** | 50 | Glial cells, astrocytes | |
| Peripherin | 57 | Peripheral neurons | |
| Type IV*** | 40,64 | ||
| NF-L | 62 | Mature neurons | |
| NF-M | 110 | Mature neurons | |
| NF-H | 130 | Mature neurons | |
| α-internexin | 66 | Developing brains | |
| Type V | 31,40,69 | ||
| Lamin A/C | 62–72 | Nucleus | |
| Lamin B | 65–68 | Nucleus | |
| Type VI | 4,5,38,52,64,73,79,88,90,100 | ||
| Synemin | 187 | Muscle, brain, liver | |
| Nestin | 220 | Developing neurons/muscles | |
| Paranemin | 178 | Muscle | |
| IFAPs: | |||
| Plectin | 500 | Striated muscle, epithelia Nuclear envelop | 20,46,99,116,118 |
| Syncoilin | 64 | Striated muscle, COS-7 cells | 6,7,11,76,83 |
| Nesprin-3 | 117 | Kerotinocytes | 56,118 |
*
Molecular weight
**
Glial fibrillary acidic protein
***
NF, neurofilament; L, M and H = low, medium and high molecular weight.