Table 1.

Kinetic rate equations for the concentrations of each of the eight types of molecule found in the MAPK cascade (Kholodenko 2000)

d[MKKK]/dt = v2−v1

d[MKKK-P]/dt = v1−v2

d[MKK]/dt = v6−v3

d[MKK-P]/dt = v3 + v5−v4−v6

d[MKK-PP]/dt = v4−v5

d[MAPK]/dt = v10−v7

d[MAPK-P]/dt = v7 + v9−v8−v10

d[MAPK-PP]/dt = v8−v9

Moiety conservation relations:

[MKKK]total = [MKKK] + [MKKK-P] = 100

[MKK]total = [MKK] + [MKK-P] + [MKK-PP] = 300

[MAPK]total = [MAPK] + [MAPK-P] + [MAPK-PP] = 300