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. Author manuscript; available in PMC: 2008 Jun 1.
Published in final edited form as: Aging Cell. 2008 Jan 31;7(3):335–343. doi: 10.1111/j.1474-9726.2008.00377.x

Figure 3.

Figure 3

Effect of age on proliferation of human marrow stromal cells (hMSCs). (A): Proliferation rate was determined by counting cells with a hemacytometer. The hMSCs isolated from younger subjects (< 50 years) expanded more rapidly than hMSCs obtained from older (≥55 years) subjects (only 4 shown here for legibility). (B): Cell population doubling time (hours) of hMSCs obtained from all 19 subjects showed a significant correlation with age (r=0.62, p=0.005, Spearman rank order correlation). Inset: hMSCs isolated from 16 older subjects had a significantly longer cell doubling time than cells obtained from 3 younger subjects (p=0.0021, Mann-Whitney test).