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. Author manuscript; available in PMC: 2008 Jun 1.
Published in final edited form as: Aging Cell. 2008 Jan 31;7(3):335–343. doi: 10.1111/j.1474-9726.2008.00377.x

Figure 5.

Figure 5

Effect of age on p53 pathway genes in human marrow stromal cells (hMSCs). (A): An age-related increase in p53, p21, and BAX gene expression was detected by RT-PCR. (B): Semi-quantitative RT-PCR analysis indicates significantly more expression of p53, p21, and BAX genes (normalized to internal control GAPDH) in hMSCs obtained from older subjects (n=9, ≥55-years), compared with hMSCs obtained from younger subjects (n=3, <50-years) (*p<0.01 and #p<0.05, Mann-Whitney test). Each lane indicates age and gender of the subject.