Table 3.
Characterization of Circadian Rhythm Parameters
| A | Number of subjects with Significant amplitudes | Mean fitted amplitude | Mean fitted maxima H:min ± SD |
|---|---|---|---|
| PER2 | 11/24 (46%) | 388.1 ± 700.8 | 09:30 ± 05:39 |
| BMAL1 | 8/24 (33%) | 751.6 ± 737.8 | 14:02 ± 04:31 |
| PER3 | 20/24 (83%) | 1914.9 ± 2396.6 | 05:32 ± 02:47 |
| Cortisol | 23/24 (96%) | 111.6 ± 44.4 | 10:49 ± 01:37 |
| Melatonin | 24/24 (100%) | 31.6 ± 15.6 | 04:20 ± 01:18 |
| B | |||
| PER2 | 8/24 (33%) | 0.01 ± 0.01 | 08:06 ± 05:23 |
| BMAL1 | 8/24 (33%) | 0.03 ± 0.03 | 15:06 ± 04:28 |
| PER3 | 19/24 (79%) | 0.08 ± 0.13 | 06:05 ± 02:14 |
Percentage of subjects with significant amplitudes for circadian markers and mean fitted amplitudes (± SD) and mean fitted maxima (time ± SD) for (A) clock gene (expressed as relative copy number), cortisol (nmol/L) and melatonin rhythms (pg/mL), and (B) clock gene rhythms expressed as relative copy number normalized to GAPDH. PER3 amplitude is significantly greater than BMAL1 and PER2 amplitudes when expressed as relative copy number (P = 0.031 and 0.006, respectively) and when normalized against GAPDH (P = 0.05 and 0.01, respectively).