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. 2008 Jun 11;3(6):e2401. doi: 10.1371/journal.pone.0002401

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Upon VEGF stimulation, the expression of Notch signaling genes, including the Dll4 ligand and the Notch1/4 receptors, as well as downstream targets of Notch signaling, including Hey2 and ephrinB2 [44], is induced in endothelial cells. Foxc1 and Foxc2 transcription factors directly control Dll4 and Hey2 transcription, while it remains speculative whether Foxc proteins function downstream of VEGF. Foxc2 is involved in the Su(H)-NICD transcriptional complex for the induction of Hey2 expression. Foxc proteins may also regulate expression of Nrp1, the arterial-specific co-receptor for VEGF (dashed arrow), thereby controlling the positive feedback loop of VEGF signaling.