Figure 2.

The effect of GnRH on ERK-1/-2 (p44/p42) activation in ovarian cancer line. The phosphorylated form (P-MAPK) normalized by total form (T-MAPK) was analyzed in a dose-dependent manner by immunoblot analysis in OVCAR-3 cells treated with GnRH. Values are represented as the mean ± SD of three individual experiments. a, P < 0.05 versus untreated control. [Reproduced, permission with, from: Kang SK, Tai CJ, Cheng KW, Leung PC; "Gonadotropin-releasing hormone activates mitogen-activated protein kinase in human ovarian and placental cells" in: Mol Cell Endocrinol 2000, 170:143–151. Copyright from Elsevier]