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. 2003 Oct 7;1:71. doi: 10.1186/1477-7827-1-71

Figure 3.

Figure 3

Effect of FSH in the presence or absence of PD98059 on ERK-1/-2 (p44/p42) activation. The P-MAPK normalized by T-MAPK was analyzed in a dose-dependent manner by immunoblot analysis in IOSE-29 cells treated with FSH. Data are shown as the means of three individual experiments, and are presented as the mean ± SD. a, P < 0.05 vs. untreated control; b, P < 0.05 vs. FSH (100 ng/ml) treatment; c, P < 0.05 vs. PD98059 (50 μM) treatment. 1, untreated control; 2, FSH (10 ng/ml) treatment; 3, FSH (100 ng/ml) treatment; 4, FSH (1000 ng/ml) treatment; 5, FSH (100 ng/ml) treatment; 6, FSH (100 ng/ml) plus PD98059 (50 μM) treatment; 7, PD98059 (50 μM) treatment. [Reproduced, permission with, from: Choi KC, Kang SK, Tai CJ, Auersperg N, Leung PC; "Follicle-stimulating hormone activates mitogen-activated protein kinase in preneoplastic and neoplastic ovarian surface epithelial cells" in: J Clin Endocrinol Metab 2002, 87:2245–2253. Copyright from Endocrine Society]