Table 2.
A summary of SF-1 target genes. (After Hammer and Ingraham, Ref. [11], updated) The cell types where the studies were conducted are presented. Studies in vivo using transgenic approaches are specified. Basal: SF-1 is required for basal promoter activity of the gene being studied. Induction: SF-1 participates to the cAMP responsiveness of the gene. A different induction signal is stated. N.D. SF-1 implication in the cAMP responsiveness was not determined. Lower case letters before the names of the promoters correspond to the species that were studied (h: human; r: rat; b: bovine; m: mouse).
| Gene promoter | Cell type /Transgenic technique | Basal activity/induction by cAMP | Bibliography |
| hP450scc | Additive transgenesis, H-295 | basal + induction | [79,80] |
| rP450scc | MA-10, rat granulosa | basal | [138,188] |
| bP450scc | Y1, bovine luteal cells, COS1 | basal + induction | [162] |
| h3β-HSD type II | H295, HeLa | basal + N.D. | [189] |
| mCYP21 | Y1 | basal + N.D. | [2,190] |
| hCYP11B1 | Y1, H295 | basal + induction | [78,81] |
| bCYP11B1 | Y1, I-10 (Leydig) | basal + induction. | [191,192] |
| hCYP17 | H295 | basal + induction | [47,82,183,185] |
| bCYP17 | Y1, COS-1 | basal + induction | [83,84] |
| rCYP19 | R2C, H450, Y1 | basal + induction | [86,164,193,194] |
| hCYP19 | Bovine luteal cells | basal + induction | [85] |
| h/mCYP11B2 | H295 | inhibition by SF-1 | [78] |
| AKR1-B7 | Additive transgenesis, HeLa, CV-1 | basal | [42,90-92] |
| HDL-R/SR-BI | Y1, HTB9 | basal + induction | [195-198] |
| SCP2 | Y1, HTB9 | basal + induction | [199] |
| hStAR | Y1, BeWo, H295 | basal + induction | [200-203] |
| mStAR | Y1, MA-10 | basal | [112] |
| rStAR | Y1, HTB9 (human bladder carcinoma) | basal + induction | [204] |
| bStAR | HeLa | basal + induction | [205] |
| HMG-CoA reductase | CV-1, MA-10 | basal + N.D. | [89] |
| hMC2R | H295-R | basal + induction | [206,207] |
| mMC2R | Y1 | basal + N.D. | [208] |
| mFSH-R | HEK-293 | basal | [60] |
| rFSH-R | JEG-3 | basal + inhibition of PKA induction | [209] |
| rLH-R | Granulosa | basal inhibition | [210] |
| R-GNRH | αT3-1 | basal | [61,62,211,212] |
| LHβ | Additive transgenesis, LβT2, αT3-1, | basal + induction by GnRH in association with Sp1, EGR-1 and Ptx1 | [58,156,157,213,214] |
| hαGSU | LβT2 gonadotropes | basal + induction by GnRH | [215] |
| Neuronal mNOS | αT3-1, NIH3T3 | basal | [96] |
| b-ocytocin | TM4 | basal | [216,217] |
| PRL-R | MLTC (Leydig) | basal | [218] |
| MIS | Knock-in mice, HeLa, JEG-3 | basal | [104,107,108] |
| DAX-1 | Additive transgenesis, H295, JEG-3 | basal | [187,219-221] |
| RLF/INSL3 | MA-10, HeLa, mLTC-1, HEK293 | basal | [109,110] |
| α-inhibin | tsa, GRMO2 granulosa | basal + induction | [163] |