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. 1996 Nov 12;93(23):12840–12844. doi: 10.1073/pnas.93.23.12840

Figure 3.

Figure 3

Dose- and time-dependent correction of splicing in oligonucleotide-treated IVS2-654 NIH 3T3 cells. RT-PCR assay. (A) Cells treated with increasing concentrations of the oligonucleotide targeted to the aberrant 5′ splice site (Upper) or of the control, scrambled oligonucleotide (Lower). (B) Time course of the correction of splicing after termination of treatment with 0.2 μM oligonucleotide targeted to the cryptic 3′ splice site activated by the IVS2-654 mutation. All designations are as in Figs. 1 and 2.