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MEK, ERK, and SAPK are required for full induction of the cyclin D1 promoter by small t antigen. JEG-3 cells were transfected with either (A) the activating MEK mutants, MEKΔN3, and MEKΔN3 S218E/S222D or (B) wild type small t and the expression plasmids encoding either dominant negative mutants of MEK (MEKC), p42ERK (MAPKi), SEK, or the MKP-1 expression vector encoding a dual specificity Thr/Tyr phosphatase.
