Table 3.
Joint segregation of CDKN2L1 genotypes with pigmentation and tumor phenotypes in X. helleri × (X. maculatus Jp 163 B × X. helleri) backcross hybrids
| Phenotype† | No. of parentals | No. of recombinants | r‡ | χ2 |
|---|---|---|---|---|
| Lp | 7 | 10 | 0.59 | 0.5 |
| Hp | 30 | 11 | 0.27 | 8.8** |
| Lp + Hp | 37 | 21 | 0.36 | 6.1* |
| UV-HNL | 28 | 3 | 0.10 | 20.2** |
| UV-HCM | 17 | 2 | 0.11 | 11.8** |
Lp, light pigmentation phenotype; Hp, heavy pigmentation phenotype; UV-HNL, UV-induced hyperplastic nodular lesions; UV-HCM, UV-induced histologically confirmed melanomas.
Recombination fraction.
, P < 0.05.
, P < 0.01.
, P < 0.001.