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Model of competition between the PGK–Neo cassette and the individual granzyme promoters for a productive interaction with a putative LCR. Insertion of PGK–Neo may disrupt normal interactions between the putative LCR and the granzyme genes, leading to activation of the PGK–Neo gene and inactivation of multiple genes within the locus. This disruption is position-specific, since insertion of PGK–Neo into the cathepsin G gene has minimal effects on granzyme gene expression.
