Figure 3.

Blockade of LTαβ/LTβR interactions results in abnormal splenic architecture. Splenic tissue sections from mice expressing either low (A, C, and E) or high (B, D, and F) levels of the LTβR–Fc transgene, as described in Fig. 2. Formalin-fixed sections were stained with hematoxylin/eosin (A–D). A single arrow represents the location of the central arterioles, and a double arrow defines the marginal zones. Frozen tissue sections were stained with antibodies specific for T-cell (red) and B-cell (green) antigens (E and F), as described in Fig. 2. (A, B, E, and F, ×100; C and D, ×400.)