Figure 4.
Control of tumor growth by high-avidity, mdm100-specific CTL. (A) Eight C57BL/10 mice were injected subcutaneously with 105 RMA lymphoma cells (□) or with 105 lymphoma cells together with 106 CTL (○). (B) Eight C57BL/10 mice were similarly injected with 5 × 105 RMA lymphoma cells (□) or with 5 × 105 lymphoma cells together with 5 × 105 CTL (○). (C) Ten C57BL/6 mice were injected with either 105 B16-F10 melanoma cells (□), or with 105 B16-F10 cells together with 106 CTL (○). Similar results were obtained when either individual high-avidity CTL clones or a mixture of clones were used for these experiments. Mice were monitored daily and the tumor growth for each individual mouse is shown. The crosses indicate that the mice died or were sacrificed because of large tumor burden.