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The relative Aβ level secreted in the various stable cell lines treated with L-685,458. Aβ40 (A) and Aβ42 (B) were measured by ELISA 24 hours post treatment with the γ-secretase inhibitor L-685,458 (n = 2). The untreated samples were used for normalization. H125.3-16 (APP-Sw, ▽), APA2 (APP-Sw + PS1, △), APB10 (APP-Sw + PS1-D385TG, ○), APC5 (APP-Sw + PS1-D257TG/D385TG, +), APD3 (APP-Sw + PS1-M146V, ▲) and H167-11 (APPV642F, □).
