Table 2.

Examination of Aβ values from conditioned media of HEK-293 derived stable cell lines expressing both Swedish APP and each of PS1 genes.

Cell Line	Transfected PS1 Constructs	Aβ1–40 (pg/ml)	Aβ1–42 (pg/ml)	Ratio of Aβ42/Aβ
H125.3-16	----	3152 ± 47 (n = 6)	337 ± 36 (n = 6)	0.097 ± 0.010
"	PS1	8379 ± 170 (n = 3)	1123 ± 20 (n = 6)	0.118 ± 0.002
"	PS1-M146V	9507 ± 129 (n = 3)	2627 ± 52 (n = 3)	0.217 ± 0.004**
"	PS1-D257TG	9716 ± 192 (n = 3)	1099 ± 35 (n = 6)	0.102 ± 0.003*
"	PS1-D385TG	7783 ± 225 (n = 3)	16647 ± 799 (n = 3)	0.681 ± 0.033**
"	PS1-D257TG/D385TG	5390 ± 218 (n = 3)	6941 ± 97 (n = 3)	0.563 ± 0.008**

n = 3 to 6 wells in one experiment. Aβ represents total Aβ.

*, p < 0.001, **, p < 0.0001 as compared to PS1 wt transfected cells