Table 3.

Transient transfection of various PS1 constructs in HEK-293 cells derived stable cell lines expressing APP carrying Swedish mutation (H125-16).

Cell Line	Transfected PS1 Constructs	Ratio of Aβ42/Aβ
H125.3-16	PS1	0.082 ± 0.022
"	PS1-D385TG	0.261 ± 0.029**
"	PS1-D385TA	0.212 ± 0.007**
"	PS1-D257TA/D385TG	0.186 ± 0.010**
"	PS1- D257TG/D385TA	0.171 ± 0.005**

Aβ40 and Aβ42 levels were measured 48 hrs post-transfection.

** p < 0.01 (versus PS1 wt) N = 3

Changed residue in the DTG motif was shown in underlined.