The β-adrenergic antagonist propranolol attenuates cocaine-induced anxiety. Dbh +/− mice were treated with vehicle, the α1-adrenergic antagonist prazosin, the α2-adrenergic antagonist yohimbine, or the β-adrenergic antagonist propranolol 10 minutes prior to cocaine injection (10 mg/kg, i.p.), and mice were tested in the EPM 20 minutes later. Shown is percent open arm time during the five minute EPM test. ** p < 0.01 compared to vehicle control (N=10–17 per group).