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. Author manuscript; available in PMC: 2009 Jun 1.
Published in final edited form as: Biol Psychiatry. 2008 Feb 20;63(11):1007–1012. doi: 10.1016/j.biopsych.2007.10.018

Figure 4.

Figure 4

The β-adrenergic antagonist propranolol attenuates cocaine-induced anxiety. Dbh +/− mice were treated with vehicle, the α1-adrenergic antagonist prazosin, the α2-adrenergic antagonist yohimbine, or the β-adrenergic antagonist propranolol 10 minutes prior to cocaine injection (10 mg/kg, i.p.), and mice were tested in the EPM 20 minutes later. Shown is percent open arm time during the five minute EPM test. ** p < 0.01 compared to vehicle control (N=10–17 per group).