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Cultured AIDS-KS cells demonstrate significantly reduced MnSOD functional activity. Cellular SOD activity (units/mg protein) was determined by calculating the rate of inhibition of xanthine/xanthine oxidase reduction of acetylated cytochrome c. Although AIDS-KS cells demonstrated comparable cytosolic (CuZn) SOD function relative to age and gender matched control cells from HIV− donors, AIDS-KS MnSOD activities were significantly decreased.
