Table 1.
Human GASPID Genes, Proteins and Enzyme Specificity
| Chromosome Cluster | Gene | Protein | Activity | P1a Preference |
|---|---|---|---|---|
| 5q11.2 | GZMA | Granzyme A | Tryptic | Arg, Lys |
| GZMK | Granzyme K | Tryptic | Arg, Lys | |
| 14q11.2 | CMA1 | Chymase | Chymotryptic | Phe, Tyr, Trp, Leu |
| CTSG | Cathepsin G | Chymotryptic, tryptic, met-ase | Phe, Tyr, Met, Arg, Lys | |
| GZMH | Granzyme H | Chymotryptic | Phe, Tyr | |
| GZMB | Granzyme B | “Asp-ase” | Asp, Glu | |
| 16p13.3 | TPSG | γ-Tryptase | Tryptic | Arg, Lys |
| TPSB2 | βII & βIII Tryptase | Tryptic | Arg, Lys | |
| TPSAB1 | βI Tryptase | Tryptic | Arg, Lys | |
| ” | α-Tryptase | Nearly inactive | Arg, Lys | |
| TPSD | δ-Tryptase | Nearly inactive | ? | |
| 19p13.3 | NE/ELA2 | Neutrophil elastase | Elastolytic | Ala, Val |
| PRTN3 | Proteinase 3 | Elastolytic | Ala, Val | |
| DF | Factor D | Tryptic | Arg | |
| GZMM | Granzyme M | “Met-ase” | Leu, Ile, Met | |
| AZU1 | Azuricidin | Inactive | - |
a
P1 is the substrate amino acid on the amino-terminal side of the site of hydrolysis.