. Author manuscript; available in PMC: 2008 May 30.

Published in final edited form as: Curr Respir Med Rev. 2006 Aug;2(39):263–277. doi: 10.2174/157339806778019024

Table 3.

Native Inhibitors of Human GASPIDs

Chromosome Cluster	Protein Name	Native Inhibitor(s)
5q11.2	Granzyme A	Antithrombin III
5q11.2	Granzyme K	Bikunin
14q11.2	Mast cell chymase	α₁-Antichymotrypsin, α₂-macroglobulin, others
	Cathepsin G	α₁-Antichymotrypsin, α₂-macroglobulin, others
	Granzyme H	None known
	Granzyme B	Proteinase inhibitor 9
16p13.3	γ-Tryptase (soluble form)	α₁-Antitrypsin, secretory leukopeptidase inhibitor
	βII- & βIII-Tryptase	?Lactoferrin
	βI- & α-Tryptase	?Lactoferrin
	δ-Tryptase	None known (or needed)
19p13.3	Neutrophil elastase	α₁-Antitrypsin, α₂-macroglobulin, secretory leukopeptidase inhibitor, elafin, others
	Proteinase 3	α₁-Antitrypsin, elafin
	Factor D	None known (or needed)
	Granzyme M	Serpin SCI-CI
	Azuricidin	None known (or needed)