. Author manuscript; available in PMC: 2008 May 30.

Published in final edited form as: Curr Respir Med Rev. 2006 Aug;2(39):263–277. doi: 10.2174/157339806778019024

Table 5.

GASPID-Defective Mice

Genotype	GASPID Deficiency	Lung-Relevant Phenotype
C57Bl/6 mice	Tryptase MCP7	Airway hyporesponsiveness; resistance to allergen sensitization
Kit^W/Kit^W-v or Kit^W-sh/Kit^W-sh	Mast cell GASPIDs	Lack of mast cells; decreased allergic inflammation; increased mortality from sepsis; enhanced bacterial bronchitis and pneumonia;
Ctsc −/−	Activated chymases Activated cathepsin G Activated granzymes A & B Activated tryptase MCP6	Decreased mortality from septic peritonitis;enhanced pneumonia
Gzma −/−	Granzyme A	Defective cell killing^a
NE −/−	Neutrophil elastase	Protection from emphysema^a; defective bacterial killing^a
Gzmm −/−	Met-ase/Granzyme M	Defective control of CMV infection
Gzmb −/−	Granzyme B	Defective cell killing^a
Ctsg −/−	Cathepsin G	Defective neutrophil function^a
Mcpt1 −/−	Chymase MCP1	Delayed parasite expulsion; delayed mast cell recruitment & structure
Mcpt4 −/−	Chymase MCP4	Decreased activation of MMP gelatinases
Mcpt5 −/−	Chymase/elastase MCP5(Carboxypeptidase A3)	Resistance to ischemia-reperfusion injury

Many of these phenotypes are more dramatic when combined with other GASPID defects, as in Gzma (−/−) x Gzmb (−/−) or NE (−/−) x Ctsg (−/−) double-knockout strains (see text).